| Jumat, 21 September 2012 | ||
| Udinese vs Anzhi Makhachkala | Group A | Young Boys vs Liverpool |
| Hapoel Tel-Aviv vs Atlético Madrid | Group B | Viktoria Plzen vs Académica |
| AEL vs Borussia M'gladbach | Group C | Fenerbahce vs Marseille |
| Bordeaux vs Club Brugge | Group D | Maritimo vs Newcastle United |
| Copenhagen vs Molde | Group E | Stuttgart vs Steaua Bucuresti |
| Dnipro vs PSV Eindhoven | Group F | Napoli vs AIK |
| Racing Genk vs FC Fehervar | Group G | Sporting Lisbon vs FC Basel |
| Internazionale vs Rubin Kazan | Group H | Partizan Belgrade vs Neftchi |
| Athletic Bilbao vs Hapoel Kiryat | Group I | Lyon vs Sparta Prague |
| NK Maribor vs Panathinaikos | Group J | Tottenham vs Lazio |
| Leverkusen vs Metalist Kharkiv | Group K | Rapid Vienna vs Rosenborg |
| Levante vs Helsingborg | Group L | Twente vs Hannover 96 |
| Jumat, 05 Oktober 2012 | ||
| Anzhi Makhachkala vs Young Boys | Group A | Liverpool vs Udinese |
| Académica vs Hapoel Tel-Aviv | Group B | Atlético Madrid vs Viktoria Plzen |
| Borussia M'gladbach vs Fenerbahce | Group C | Marseille vs AEL |
| Club Brugge vs Maritimo | Group D | Newcastle United vs Bordeaux |
| Molde vs Stuttgart | Group E | Steaua Bucuresti vs Copenhagen |
| AIK vs Dinipro | Group F | PSV Eindhoven vs Napoli |
| FC Basel vs Racing Genk | Group G | FC Fehervar vs Sporting Lisbon |
| Rubin Kazan vs Partizan Belgrade | Group H | Neftchi vs Internazionale |
| Hapoel Kiryat vs Lyon | Group I | Sparta Prague vs Athletic Bilbao |
| Lazio vs NK Maribor | Group J | Panathinaikos vs Tottenham |
| Metalist Kharkiv vs Rapid Vienna | Group K | Rosenborg vs Leverkusen |
| Hannover 96 vs Levante | Group L | Helsingborg vs Twente |
| Jumat, 26 Oktober 2012 | ||
| Liverpool vs Anzhi Makhachkala | Group A | Young Boys vs Udinese |
| Atlético Madrid vs Académica | Group B | Hapoel Tel-Aviv vs Viktoria Plzen |
| AEL vs Fenerbahce | Group C | Borussia M'gladbach vs Marseille |
| Maritimo vs Bordeaux | Group D | Newcastle United vs Club Brugge |
| Steaua Bucuresti vs Molde | Group E | Stuttgart vs Copenhagen |
| Dnipro vs Napoli | Group F | PSV Eindhoven vs AIK |
| Racing Genk vs Sporting Lisbon | Group G | FC Fehervar vs FC Basel |
| Rubin Kazan vs Neftchi | Group H | Internazionale vs Partizan Belgrade |
| Lyon vs Athletic Bilbao | Group I | Sparta Prague vs Hapoel Kiryat |
| NK Maribor vs Tottenham | Group J | Panathinaikos vs Lazio |
| Rapid Vienna vs Leverkusen | Group K | Rosenborg vs Metalist Kharkiv |
| Helsingborg vs Hannover 96 | Group L | Levante vs Twente |
| Jumat, 09 November 2012 | ||
| Anzhi Makhachkala vs Liverpool | Group A | Udinese vs Young Boys |
| Académica vs Atlético Madrid | Group B | Viktoria Plzen vs Hapoel Tel-Aviv |
| Fenerbahce vs AEL | Group C | Marseille vs Borussia M'gladbach |
| Bordeaux vs Maritimo | Group D | Club Brugge vs Newcastle United |
| Copenhagen vs Stuttgart | Group E | Molde vs Steaua Bucuresti |
| AIK vs PSV Eindhoven | Group F | Napoli vs Dnipro |
| FC Basel vs FC Fehervar | Group G | Sporting Lisbon vs Racing Genk |
| Neftchi vs Rubin Kazan | Group H | Partizan Belgrade vs Internazionale |
| Athletic Bilbao vs Lyon | Group I | Hapoel Kiryat vs Sparta Prague |
| Lazio vs Panathinaikos | Group J | Tottenham vs NK Maribor |
| Leverkusen vs Rapid Vienna | Group K | Metalist Kharkiv vs Rosenborg |
| Hannover 96 vs Helsingborg | Group L | Twente vs Levante |
| Jumat, 23 November 2012 | ||
| Anzhi Makhachkala vs Udinese | Group A | Liverpool vs Young Boys |
| Académica vs Viktoria Plzen | Group B | Atlético Madrid vs Hapoel Tel-Aviv |
| Borussia M'gladbach vs AEL | Group C | Marseille vs Fenerbahce |
| Club Brugge vs Bordeaux | Group D | Newcastle United vs Maritimo |
| Molde vs Copenhagen | Group E | Steaua Bucuresti vs Stuttgart |
| AIK vs Napoli | Group F | PSV Eindhoven vs Dnipro |
| FC Basel vs Sporting Lisbon | Group G | FC Fehervar vs Racing Genk |
| Rubin Kazan vs Internazionale | Group H | Neftchi vs Partizan Belgrade |
| Hapoel Kiryat vs Athletic Bilbao | Group I | Sparta Prague vs Lyon |
| Lazio vs Tottenham | Group J | Panathinaikos vs NK Maribor |
| Metalist Kharkiv vs Leverkusen | Group K | Rosenborg vs Rapid Vienna |
| Hannover 96 vs Twente | Group L | Helsingborg vs Levante |
| Jumat, 07 Desember 2012 | ||
| Udinese vs Liverpool | Group A | Young Boys vs Anzhi Makhachkala |
| Hapoel Tel-Aviv vs Académica | Group B | Viktoria Plzen vs Atlético Madrid |
| AEL vs Marseille | Group C | Fenerbahce vs Borussia M'gladbach |
| Bordeaux vs Newcastle United | Group D | Maritimo vs Club Brugge |
| Copenhagen vs Steaua Bucuresti | Group E | Stuttgart vs Molde |
| Dnipro vs AIK | Group F | Napoli vs PSV Eindhoven |
| Racing Genk vs FC Basel | Group G | Sporting Lisbon vs FC Fehervar |
| Internazionale vs Neftchi | Group H | Partizan Belgrade vs Rubin Kazan |
| Athletic Bilbao vs Sparta Prague | Group I | Lyon vs Hapoel Kiryat |
| NK Maribor vs Lazio | Group J | Tottenham vs Panathinaikos |
| Leverkusen vs Rosenborg | Group K | Rapid Vienna vs Metalist Kharkiv |
| Levante vs Hannover 96 | Group L | Twente vs Helsingborg |
